Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 17/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6179576 | 0.87 | DHPS (0.59) | DHPS | |
| SCHEMBL6180352 | 0.80 | EDNRA (0.60) | — | |
| SCHEMBL5036558 | 0.79 | DHPS (0.48) | DHPS | |
| SCHEMBL4061451 | 0.79 | DHPS (0.58) | DHPS | |
| SCHEMBL4062097 | 0.77 | DHPS (0.51) | DHPS | |
| SCHEMBL5632776 | 0.75 | DHPS (0.43) | DHPS | |
| SCHEMBL7415372 | 0.74 | DHPS (0.50) | DHPSHTTMAPT | |
| SCHEMBL7979535 | 0.73 | EDNRB (0.50) | DHPSKDM4EHTTMAPT | |
| SCHEMBL7979436 | 0.73 | EDNRB (0.43) | DHPS | |
| SCHEMBL6585958 | 0.72 | DHPS (0.55) | DHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979822-B1 | Process for the preparation of 2-carbamoyl-pyridines | HOFFMANN LA ROCHE (CH) | 2005-11-30 | — | — | EP | claimed |
| EP-0979822-A1 | Process for the preparation of 2-carbamoyl-pyridines | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | claimed |
| EP-0979822-B1 | Process for the preparation of 2-carbamoyl-pyridines | HOFFMANN LA ROCHE (CH) | 2005-11-30 | — | — | EP | disclosed |
| US-6103902-A | Carbamoylation process | HOFFMANN-LA ROCHE INC. (US) | 2000-08-15 | — | — | US | disclosed |
| EP-0979822-A1 | Process for the preparation of 2-carbamoyl-pyridines | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | disclosed |