Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 4/20 | 0.50 |
| ▸ | EDNRA | P25101 | 4/20 | 0.50 |
| ▸ | DHPS | P49366 | 14/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979436 | 0.91 | EDNRB (0.43) | EDNRBEDNRADHPS | |
| SCHEMBL7979542 | 0.89 | DHPS (0.56) | EDNRBEDNRADHPS | |
| SCHEMBL5632776 | 0.83 | DHPS (0.43) | EDNRBEDNRADHPS | |
| SCHEMBL7993866 | 0.82 | EDNRB (0.55) | EDNRBEDNRADHPSMAPT | |
| SCHEMBL7979438 | 0.79 | DHPS (0.56) | EDNRBEDNRADHPS | |
| SCHEMBL5036558 | 0.77 | DHPS (0.48) | DHPS | |
| SCHEMBL4061451 | 0.77 | DHPS (0.58) | EDNRBEDNRADHPS | |
| SCHEMBL5035283 | 0.76 | DHPS (0.43) | EDNRBEDNRADHPSMAPT | |
| SCHEMBL7415372 | 0.76 | DHPS (0.50) | DHPSUSP2LMNAESR1TP53 | |
| SCHEMBL7993871 | 0.75 | EDNRB (0.56) | EDNRBEDNRADHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001081338-A1 | SUBSTITUTED SULFONYLAMINOPYRIMIDINES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-11-01 | — | — | WO | disclosed |