Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 2/20 | 0.59 |
| ▸ | GABRD | O14764 | 2/20 | 0.59 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.59 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.59 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.59 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.59 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.59 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.59 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.59 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.59 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.59 |
| ▸ | GABRE | P78334 | 2/20 | 0.59 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.59 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.59 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.59 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | SLC6A7 | Q99884 | 3/20 | 0.45 |
| ▸ | CCR8 | P51685 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14858253 | 0.87 | HPGD (0.62) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL28226884 | 0.86 | MEN1 (0.55) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL5338061 | 0.85 | HPGD (0.65) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL18175986 | 0.83 | PKM (0.55) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL19966525 | 0.82 | CCNT1 (0.49) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7498578 | 0.82 | LMNA (0.49) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6179175 | 0.81 | PROKR1 (0.53) | HPGDKDM4ESLC6A7LMNASMN1; SMN2 | |
| SCHEMBL20445962 | 0.79 | GABRP (0.45) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6178837 | 0.79 | MEN1 (0.54) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL21788694 | 0.77 | HRH3 (0.47) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218376-B1 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6586424-B2 | Anticancer agents; anticholesterol agents | MERCK & CO., INC. | 2003-07-01 | — | — | US | disclosed |
| US-6586423-B2 | 2-(Pyridin-2-ylamino)-thiazole-5-carbonitrile derivatives; angiogenesis inhibitors; antitumor and anticarcinogenic agents; atherosclerosis, macular degeneration, diabetic retinopathy | MERCK & CO., INC. | 2003-07-01 | — | — | US | disclosed |
| US-20030064996-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME CORP. | 2003-04-03 | — | — | US | disclosed |
| EP-1218376-A4 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | disclosed |
| US-20020147203-A1 | Tyrosine kinase inhibitors | MERCK & CO., INC. | 2002-10-10 | — | — | US | disclosed |
| EP-1218376-A1 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001017995-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020147203-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | GABRP 4158/4885GABRD 4673/4885GABRA1 4369/4885 |
| US-20030064996-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | GABRP 4158/4885GABRD 4673/4885GABRA1 4369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.