Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 15/20 | 0.56 |
| ▸ | ITGA4 | P13612 | 15/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | GHSR | Q92847 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178527 | 0.87 | ITGB1 (0.51) | ITGB1ITGA4HPGDMAPTRAB9A | |
| SCHEMBL17477398 | 0.81 | POLB (0.48) | HPGDMEN1KMT2A | |
| SCHEMBL3485567 | 0.78 | ITGB1 (0.67) | ITGB1ITGA4HPGDMAPTRAB9A | |
| SCHEMBL29612679 | 0.78 | ITGB1 (0.67) | ITGB1ITGA4HPGDMAPTRAB9A | |
| SCHEMBL8236504 | 0.77 | ITGB1 (0.56) | ITGB1ITGA4HPGDMAPTRAB9A | |
| SCHEMBL18472821 | 0.76 | ITGB1 (0.58) | ITGB1ITGA4HPGDMAPTRAB9A | |
| SCHEMBL8231040 | 0.76 | ITGB1 (0.61) | ITGB1ITGA4HPGDMAPTRAB9A | |
| SCHEMBL14561170 | 0.76 | RAB9A (0.67) | ITGB1ITGA4MAPTRAB9AMEN1 | |
| SCHEMBL5700801 | 0.76 | ITGB1 (0.67) | ITGB1ITGA4HPGDMAPTRAB9A | |
| SCHEMBL20808405 | 0.75 | ITGB1 (0.59) | ITGB1ITGA4HPGDMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091943-B1 | NON-PEPTIDYL INHIBITORS OF VLA-4 DEPENDENT CELL BINDING USEFUL IN TREATING INFLAMMATORY, AUTOIMMUNE, AND RESPIRATORY DISEASES | PFIZER PROD INC (US) | 2005-11-30 | — | — | EP | disclosed |
| US-6355662-B1 | PEPTIDE AND NONPEPTIDES AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS | PFIZER INC | 2002-03-12 | — | — | US | disclosed |
| US-6306887-B1 | AROMATIC UREAS, CARBAMATES AND TRIAMINONITRILES AND HETEROCYCLIC COMPOUNDS | PFIZER INC | 2001-10-23 | — | — | US | disclosed |