Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28418464 | 0.91 | CNR2 (0.51) | POLBMEN1KMT2AHDAC8HDAC6 | |
| SCHEMBL6180128 | 0.81 | ITGB1 (0.56) | MEN1KMT2AHPGD | |
| SCHEMBL9828810 | 0.78 | SHMT1 (0.61) | MEN1KMT2AHDAC8HDAC6CNR2 | |
| SCHEMBL10986259 | 0.78 | MEN1 (0.59) | MEN1KMT2AHDAC8HDAC6CNR2 | |
| SCHEMBL12471403 | 0.78 | POLB (0.54) | POLBHDAC8HDAC6L3MBTL1GAA | |
| SCHEMBL7398855 | 0.78 | RIPK1 (0.49) | POLBEPHX2ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL20255827 | 0.77 | KDM4E (0.62) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL25144167 | 0.77 | HPGD (0.56) | POLBMEN1KMT2AHDAC8HDAC6 | |
| SCHEMBL10982724 | 0.77 | HPGD (0.75) | POLBMEN1KMT2AHDAC8HDAC6 | |
| SCHEMBL25595163 | 0.76 | CNR2 (0.51) | POLBMEN1KMT2AHDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3186271-A1 | AZAINDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | Vida Therapeutics, Inc. (CA) | 2017-07-05 | — | — | EP | disclosed |
| WO-2016015159-A1 | AZAINDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | VIDA THERAPEUTICS, INC. (CA) | 2016-02-04 | — | — | WO | disclosed |