Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | TACR3 | P29371 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177706 | 0.90 | RAB9A (0.45) | RAB9ANPC1TACR3MAPTMAOB | |
| SCHEMBL6178510 | 0.88 | NPC1 (0.47) | RAB9ANPC1TACR3MAPTMAOB | |
| SCHEMBL6178775 | 0.88 | NPC1 (0.47) | RAB9ANPC1TACR3MAPTMAOB | |
| SCHEMBL27542898 | 0.85 | NPC1 (0.47) | RAB9ANPC1TACR3MAPTMAOB | |
| SCHEMBL5735284 | 0.84 | SMN1; SMN2 (0.49) | RAB9ANPC1MAPTKMT2AALDH1A1 | |
| SCHEMBL27542904 | 0.81 | NPC1 (0.47) | RAB9ANPC1TACR3MAPTMAOB | |
| SCHEMBL27542899 | 0.78 | RAB9A (0.45) | RAB9ANPC1TACR3MAPTMAOB | |
| SCHEMBL6183972 | 0.77 | ALDH1A1 (0.52) | RAB9ANPC1MAPTKMT2AALDH1A1 | |
| SCHEMBL6672269 | 0.76 | RAB9A (0.61) | RAB9ANPC1MAPTKMT2AALDH1A1 | |
| SCHEMBL8346676 | 0.75 | RAB9A (0.50) | RAB9ANPC1MAPTMAOBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1315805-C | Compositions and methods of use thereof achiral analogues of CC-1065 and duocarmycins | TAIHO PHARMACEUTICAL CO LTD (GB) | 2007-05-16 | — | — | CN | disclosed |
| EP-1320522-B1 | COMPOSITIONS AND METHODS OF THE USE THEREOF ACHIRAL ANALOGUES OF CC-1065 AND THE DUOCARMYCINS | TAIHO PHARMACEUTICAL CO LTD (JP) | 2005-11-23 | — | — | EP | disclosed |
| CN-1461298-A | Compositions and methods of use thereof achiral analogues of CC-1065 and duocarmycins | TAIHO PHARMACEUTICAL CO LTD (JP) | 2003-12-10 | — | — | CN | disclosed |
| US-6660742-B2 | Alkylation therapy; anticancer agent | TAIHO PHARMACEUTICAL CO. LTD. (JP) | 2003-12-09 | — | — | US | disclosed |
| US-20030073731-A1 | Compositions and methods of the use thereof achiral analogues of CC-1065 and the duocarmycins | MEDIMMUNE LIMITED (GB) | 2003-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073731-A1 | Compositions and methods of the use thereof achiral analogues of CC-1065 and the duocarmycins | DDB1, ERCC2, SSU72 | RAB9A 3639/4885NPC1 2541/4885TACR3 2856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.