Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 3/20 | 0.45 |
| ▸ | SRC | P12931 | 10/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 4/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6180394 | 0.81 | FGFR1 (0.39) | GHSRSRCFGFR1KDM4ECCR2 | |
| SCHEMBL6180949 | 0.74 | GHSR (0.54) | GHSRMEN1KMT2A | |
| SCHEMBL6177738 | 0.72 | GHSR (0.45) | GHSRKMT2A | |
| SCHEMBL6178245 | 0.66 | GHSR (0.58) | GHSRMEN1PIM1KMT2ATDP1 | |
| SCHEMBL6176281 | 0.65 | GHSR (0.43) | GHSR | |
| SCHEMBL6180015 | 0.64 | GHSR (0.53) | GHSRKMT2A | |
| SCHEMBL6180568 | 0.64 | GHSR (0.61) | GHSRMEN1KMT2A | |
| SCHEMBL6177474 | 0.64 | GHSR (0.61) | GHSRMEN1KMT2A | |
| SCHEMBL6179661 | 0.64 | GHSR (0.65) | GHSRMEN1KMT2A | |
| SCHEMBL6181396 | 0.63 | GHSR (0.54) | GHSRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105376-B1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMA (JP) | 2005-02-09 | — | — | EP | disclosed |
| US-6576656-B1 | Such as 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-carbamoyl-3-hydroxy-3-(2 -chlorophenyl)oxindole; growth hormone releaser | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2003-06-10 | — | — | US | disclosed |