Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 12/20 | 0.41 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 3/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627521 | 0.80 | ALDH1A1 (0.39) | ALDH1A1TP53MAPTHTR6DRD1 | |
| SCHEMBL3973547 | 0.80 | POLB (0.49) | TP53MAPTPOLBCASP6GHSR | |
| SCHEMBL2496770 | 0.77 | POLB (0.49) | ALDH1A1MAPTHTR6POLBCASP6 | |
| SCHEMBL128573 | 0.76 | ALDH1A1 (0.44) | ALDH1A1TP53MAPTHTR6DRD1 | |
| SCHEMBL6177738 | 0.73 | GHSR (0.45) | GHSR | |
| SCHEMBL6179770 | 0.72 | GHSR (0.42) | POLBCASP6GHSR | |
| SCHEMBL5981551 | 0.70 | ALDH1A1 (0.47) | ALDH1A1TP53MAPTHTR6DRD1 | |
| SCHEMBL6180394 | 0.70 | FGFR1 (0.39) | ALDH1A1TP53MAPTHTR6DRD1 | |
| SCHEMBL6180123 | 0.68 | GHSR (0.69) | POLBGHSR | |
| SCHEMBL5982243 | 0.67 | KCNQ3 (0.46) | ALDH1A1TP53MAPTHTR6ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105376-B1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMA (JP) | 2005-02-09 | — | — | EP | disclosed |
| US-6576656-B1 | Such as 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-carbamoyl-3-hydroxy-3-(2 -chlorophenyl)oxindole; growth hormone releaser | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2003-06-10 | — | — | US | disclosed |