Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4605920 | 0.89 | GAA (0.53) | SIGMAR1GAAMAPTEPHX2 | |
| SCHEMBL10478067 | 0.89 | EPHX2 (0.54) | SIGMAR1GAAMAPTKCNH2EPHX2 | |
| SCHEMBL31364605 | 0.86 | ALDH1A1 (0.31) | — | |
| SCHEMBL31364603 | 0.86 | ALDH1A1 (0.31) | — | |
| SCHEMBL1753940 | 0.84 | KCNH2 (0.50) | KCNH2 | |
| SCHEMBL8617900 | 0.83 | RAB9A (0.43) | GAACA12CA1CA2 | |
| SCHEMBL10743482 | 0.81 | HTR2A (0.42) | SIGMAR1KCNH2 | |
| SCHEMBL4390050 | 0.79 | HRH3 (0.45) | SIGMAR1MAPT | |
| SCHEMBL11475089 | 0.79 | CHRM2 (0.54) | SIGMAR1 | |
| SCHEMBL27516300 | 0.78 | L3MBTL1 (0.45) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140909-B1 | NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORP (US) | 2005-07-06 | — | — | EP | disclosed |
| US-6432959-B1 | ANTITUMOR AGENTS | SCHERING CORPORATION | 2002-08-13 | — | — | US | disclosed |
| EP-1140909-A1 | NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039119-A1 | NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |