Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088945 | 0.80 | CYP11B1 (0.55) | CYP11B1CYP11B2LOXL2HRH3 | |
| SCHEMBL14415972 | 0.79 | CYP11B1 (0.50) | CYP11B1CYP11B2IDO1SIGMAR1HTR2A | |
| SCHEMBL13470151 | 0.74 | CYP11B1 (0.49) | CYP11B1CYP11B2SIGMAR1HTR2ATAAR1 | |
| SCHEMBL8971686 | 0.73 | CYP11B1 (0.68) | CYP11B1CYP11B2IDO1HPGDSHTR2A | |
| SCHEMBL20439593 | 0.73 | KCNH2 (0.34) | — | |
| SCHEMBL1502108 | 0.72 | CYP11B1 (0.62) | CYP11B1CYP11B2IDO1HPGDSP2RX7 | |
| SCHEMBL9783717 | 0.72 | CYP11B1 (0.41) | CYP11B1CYP11B2IDO1LTA4HHPGDS | |
| SCHEMBL9783703 | 0.72 | CYP11B1 (0.39) | CYP11B1CYP11B2IDO1LTA4HHRH3 | |
| SCHEMBL531371 | 0.71 | CYP11B1 (0.73) | CYP11B1CYP11B2IDO1HPGDSP2RX7 | |
| SCHEMBL6928442 | 0.71 | CYP11B1 (0.56) | CYP11B1CYP11B2IDO1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140909-B1 | NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORP (US) | 2005-07-06 | — | — | EP | disclosed |
| CN-1181069-C | Novel inhibitors of farnesyl-protein transferase | ���鹫˾ | 2004-12-22 | — | — | CN | disclosed |
| US-6432959-B1 | ANTITUMOR AGENTS | SCHERING CORPORATION | 2002-08-13 | — | — | US | disclosed |
| CN-1346355-A | Novel inhibitors of farnesyl-protein transferase | SCHERING CORP (US) | 2002-04-24 | — | — | CN | disclosed |
| EP-1140909-A1 | NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039119-A1 | NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |