Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178979 | 0.90 | PSEN1 (0.57) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL6179184 | 0.87 | TRPA1 (0.57) | TRPA1LMNAMAPTPSEN1PSEN2 | |
| SCHEMBL6178957 | 0.86 | TRPA1 (0.56) | TRPA1LMNAMAPTPSEN1PSEN2 | |
| SCHEMBL6178952 | 0.86 | TRPA1 (0.56) | TRPA1LMNAMAPTPSEN1PSEN2 | |
| SCHEMBL6178012 | 0.84 | CYP3A4 (0.62) | TRPA1LMNAMAPTKDM4ETP53 | |
| SCHEMBL6176638 | 0.82 | TRPA1 (0.70) | TRPA1LMNAMAPTPSEN1PSEN2 | |
| SCHEMBL6179258 | 0.82 | PSEN1 (0.67) | TRPA1LMNAMAPTPSEN1PSEN2 | |
| SCHEMBL6176643 | 0.82 | TRPA1 (0.70) | TRPA1LMNAMAPTPSEN1PSEN2 | |
| SCHEMBL6179250 | 0.82 | PSEN1 (0.67) | TRPA1LMNAMAPTPSEN1PSEN2 | |
| SCHEMBL6180434 | 0.81 | TRPA1 (0.47) | TRPA1LMNAPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165510-B1 | 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | EP | claimed |