Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6179184 | 0.84 | TRPA1 (0.57) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL6178979 | 0.84 | PSEN1 (0.57) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL6177953 | 0.83 | TRPA1 (0.54) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL6177949 | 0.83 | TRPA1 (0.54) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL6180591 | 0.81 | TRPA1 (0.48) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL6178185 | 0.80 | TRPA1 (0.53) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL6180512 | 0.80 | LMNA (0.65) | TRPA1LMNAGAA | |
| SCHEMBL6180550 | 0.79 | PSEN1 (0.63) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL6180546 | 0.79 | PSEN1 (0.63) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL6180330 | 0.79 | TRPA1 (0.73) | TRPA1LMNAPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165510-B1 | 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | EP | claimed |