Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015580 | 0.86 | MAPT (0.38) | RAB9ALMNAMAPTL3MBTL1MCHR1 | |
| SCHEMBL3125608 | 0.84 | CARM1 (0.49) | RAB9ANPC1DRD4EPHX1GAA | |
| SCHEMBL4778134 | 0.81 | GPR119 (0.52) | RAB9ANPC1KDM4EMAPTL3MBTL1 | |
| SCHEMBL4771588 | 0.78 | KMT2A (0.41) | MAPTTDP1KMT2A | |
| SCHEMBL21623786 | 0.78 | KMT2A (0.58) | RAB9ANPC1MAPTKMT2A | |
| SCHEMBL1866719 | 0.77 | KMT2A (0.41) | RAB9AEPHX1TSHRSIGMAR1L3MBTL1 | |
| SCHEMBL4097076 | 0.77 | CCR5 (0.42) | RAB9ANPC1KDM4EATML3MBTL1 | |
| SCHEMBL5273038 | 0.77 | MAPT (0.45) | RAB9ANPC1LMNAMAPTL3MBTL1 | |
| SCHEMBL16013886 | 0.77 | KMT2A (0.41) | RAB9ANPC1GAAMAPTL3MBTL1 | |
| SCHEMBL4777118 | 0.77 | GAA (0.49) | RAB9ALMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0844877-B1 | USE OF OXIDO-SQUALENE CYCLASE INHIBITORS TO LOWER BLOOD CHOLESTEROL | ASTRAZENECA AB (SE) | 2005-01-26 | — | — | EP | disclosed |
| CN-1164232-A | Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents | ZENECA LTD (GB) | 1997-11-05 | — | — | CN | disclosed |