Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6181099 | 0.86 | PPARG (0.54) | PPARGSCN9AALDH1A1GAAHTT | |
| SCHEMBL6180764 | 0.74 | THRB (0.37) | PPARGALDH1A1GAAHTT | |
| SCHEMBL6134825 | 0.73 | PPARG (0.58) | PPARGHDAC1HDAC8HDAC6PTPN1 | |
| SCHEMBL6181163 | 0.71 | PPARG (0.55) | PPARGALDH1A1GAAHDAC1HDAC8 | |
| SCHEMBL6172090 | 0.70 | PPARG (0.54) | PPARGHDAC1HDAC8HDAC6 | |
| SCHEMBL6168579 | 0.70 | ERAP2 (0.47) | PPARGALDH1A1GAAHTTHDAC1 | |
| SCHEMBL6305809 | 0.70 | PPARG (0.54) | PPARGPTPN1 | |
| SCHEMBL5881961 | 0.70 | PPARG (0.54) | PPARG | |
| SCHEMBL6306158 | 0.70 | PPARG (0.68) | PPARG | |
| SCHEMBL5882208 | 0.70 | PPARG (0.75) | PPARGHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000932-B9 | AROMATIC RING DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2005-12-28 | — | — | EP | disclosed |
| EP-1000932-B1 | AROMATIC RING DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-09-15 | — | — | EP | disclosed |
| US-6242474-B1 | SULFONYLCARBAMOYLALKYLIMIDAZOLE DERIVATIVES; ANTIDIABETIC AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-05 | — | — | US | disclosed |
| EP-1000932-A1 | AROMATIC RING DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-17 | — | — | EP | disclosed |