Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6181103 | 0.86 | THRB (0.40) | THRBHTTALDH1A1GAAPPARG | |
| SCHEMBL6180762 | 0.74 | PPARG (0.52) | HTTALDH1A1GAAPPARG | |
| SCHEMBL8044091 | 0.64 | BMP1 (0.45) | HTTALDH1A1GAALMNANPSR1 | |
| SCHEMBL4031996 | 0.62 | HTT (0.49) | HTTALDH1A1GAALMNAKDM4E | |
| SCHEMBL29822237 | 0.61 | KDM4E (0.66) | ALDH1A1GAALMNAKDM4EHSD17B10 | |
| SCHEMBL4311940 | 0.61 | KDM4E (0.66) | ALDH1A1GAALMNAKDM4EHSD17B10 | |
| SCHEMBL28045482 | 0.61 | SIRT1 (0.46) | THRBHTTALDH1A1GAALMNA | |
| SCHEMBL11508951 | 0.60 | ALDH1A1 (0.59) | ALDH1A1GAALMNAKDM4E | |
| SCHEMBL23524965 | 0.60 | KDM4E (0.56) | ALDH1A1GAALMNAKDM4EHSD17B10 | |
| SCHEMBL9119625 | 0.60 | KDM4E (0.60) | ALDH1A1GAALMNAKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000932-B9 | AROMATIC RING DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2005-12-28 | — | — | EP | disclosed |
| EP-1000932-B1 | AROMATIC RING DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-09-15 | — | — | EP | disclosed |
| US-6242474-B1 | SULFONYLCARBAMOYLALKYLIMIDAZOLE DERIVATIVES; ANTIDIABETIC AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-05 | — | — | US | disclosed |
| EP-1000932-A1 | AROMATIC RING DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-17 | — | — | EP | disclosed |