Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | P4HB | P07237 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5732709 | 0.88 | LMNA (0.40) | LMNAKDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL6179116 | 0.88 | LMNA (0.45) | LMNAKDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL5734217 | 0.80 | ALDH1A1 (0.48) | LMNAKDM4EALDH1A1HPGDCYP3A4 | |
| SCHEMBL5734528 | 0.80 | LMNA (0.43) | LMNAKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL5733054 | 0.77 | LMNA (0.47) | LMNAKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL21943619 | 0.76 | ALDH1A1 (0.46) | LMNAKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL14234930 | 0.73 | LMNA (0.42) | LMNAKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL5735475 | 0.72 | LMNA (0.49) | LMNAKDM4EALDH1A1HPGDPOLB | |
| Centanamycin SCHEMBL29441389 | 0.71 | LMNA (0.46) | LMNAKDM4EALDH1A1HPGDPOLB | |
| Centanamycin SCHEMBL5733476 | 0.71 | LMNA (0.46) | LMNAKDM4EALDH1A1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320522-B1 | COMPOSITIONS AND METHODS OF THE USE THEREOF ACHIRAL ANALOGUES OF CC-1065 AND THE DUOCARMYCINS | TAIHO PHARMACEUTICAL CO LTD (JP) | 2005-11-23 | — | — | EP | claimed |