Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 13/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12444984 | 0.78 | TGFBR1 (0.57) | TGFBR1MAPK14MAPKAPK2DYRK1B | |
| SCHEMBL6180820 | 0.77 | TGFBR1 (0.48) | TGFBR1MAPK14 | |
| SCHEMBL6180702 | 0.75 | ROCK2 (0.49) | TGFBR1 | |
| SCHEMBL373292 | 0.75 | TGFBR1 (0.66) | TGFBR1MAPK14 | |
| SCHEMBL6178605 | 0.75 | TGFBR1 (0.70) | TGFBR1MAPK14MAPKAPK2 | |
| SCHEMBL29358505 | 0.75 | TGFBR1 (0.70) | TGFBR1MAPK14MAPKAPK2DYRK1B | |
| SCHEMBL373524 | 0.75 | TGFBR1 (0.70) | TGFBR1MAPK14MAPKAPK2DYRK1B | |
| SCHEMBL8586635 | 0.74 | BACE1 (0.48) | PRSS1 | |
| SCHEMBL6179158 | 0.74 | TGFBR1 (0.53) | TGFBR1MAPK14 | |
| SCHEMBL24312340 | 0.74 | TGFBR1 (0.56) | TGFBR1MAPK14MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355903-B1 | PYRAZOLE DERIVATIVES AGAINST TGF OVEREXPRESSION | SMITHKLINE BEECHAM CORP (US) | 2005-03-16 | — | — | EP | claimed |
| EP-1355903-B1 | PYRAZOLE DERIVATIVES AGAINST TGF OVEREXPRESSION | SMITHKLINE BEECHAM CORP (US) | 2005-03-16 | — | — | EP | disclosed |