Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3144573 | 0.89 | UBE2T (0.40) | SMN1; SMN2KMT2AUBE2TMEN1HTT | |
| Nitric Acid SCHEMBL637677 | 0.76 | NPC1 (0.48) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| Nitric Acid SCHEMBL28996492 | 0.75 | NPC1 (0.47) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| Nitric Acid SCHEMBL6702127 | 0.73 | NPC1 (0.48) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| Nitric Acid SCHEMBL11650844 | 0.73 | MAPT (0.37) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL28277033 | 0.72 | MAPT (0.44) | MAPTSMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL6141681 | 0.70 | LMNA (0.47) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| Nitric Acid SCHEMBL9454024 | 0.65 | MAPT (0.38) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| Nitric Acid SCHEMBL7620986 | 0.64 | NOS1 (0.77) | MAPTNPC1RAB9AHTTALDH1A1 | |
| SCHEMBL2085730 | 0.62 | KMT2A (0.44) | MAPTNPC1RAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546548-B1 | Guanidinyl alkyl-1,1-bis phosphonic acid derivatives, process for their preparation and their use | HOECHST AG (DE) | 1997-05-02 | — | — | EP | claimed |
| EP-0546548-A1 | Guanidinyl alkyl-1,1-bis phosphonic acid derivatives, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-06-16 | — | — | EP | claimed |
| EP-1523473-B1 | INDOLINE DERIVATIVES SUBSTITUTED IN POSITION 6, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2013-02-27 | — | — | EP | disclosed |
| EP-1527046-A1 | INDOLINE DERIVATIVES SUBSTITUTED IN POSITION 6, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-05-04 | — | — | EP | disclosed |
| EP-1523473-A1 | INDOLINE DERIVATIVES SUBSTITUTED IN POSITION 6, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-04-20 | — | — | EP | disclosed |
| WO-2004009546-A1 | INDOLINE DERIVATIVES SUBSTITUTED IN POSITION 6, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-01-29 | — | — | WO | disclosed |
| WO-2004009547-A1 | INDOLINE DERIVATIVES SUBSTITUTED IN POSITION 6, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-01-29 | — | — | WO | disclosed |
| EP-0680469-B1 | AMINOACID DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR PREPARING THE SAME | BOEHRINGER INGELHEIM PHARMA (DE) | 2000-04-26 | — | — | EP | disclosed |
| EP-0546548-B1 | Guanidinyl alkyl-1,1-bis phosphonic acid derivatives, process for their preparation and their use | HOECHST AG (DE) | 1997-05-02 | — | — | EP | disclosed |
| EP-0416499-B1 | Benzoylguanidines, process for their preparation, their use as medicaments as well as medicament containing them | HOECHST AG (DE) | 1995-04-26 | — | — | EP | disclosed |
| EP-0546548-A1 | Guanidinyl alkyl-1,1-bis phosphonic acid derivatives, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-06-16 | — | — | EP | disclosed |
| EP-0416499-A2 | Benzoylguanidines, process for their preparation, their use as medicaments as well as medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-13 | — | — | EP | disclosed |