Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.43 |
| ▸ | ALPL | P05186 | 2/20 | 0.43 |
| ▸ | XIAP | P98170 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL28996492 | 0.98 | NPC1 (0.47) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL369236 | 0.88 | TSHR (0.48) | MEN1KMT2AALDH1A1TSHRENPP3 | |
| Nitric Acid SCHEMBL6702127 | 0.86 | NPC1 (0.48) | NPC1RAB9AMAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6943796 | 0.86 | TSHR (0.47) | MEN1KMT2AALDH1A1TSHRENPP3 | |
| Acetic Acid SCHEMBL10353741 | 0.83 | TSHR (0.50) | MEN1KMT2AALDH1A1TSHRENPP3 | |
| Nitric Acid SCHEMBL11650844 | 0.76 | MAPT (0.37) | NPC1RAB9AMAPTMEN1KMT2A | |
| Nitric Acid SCHEMBL6182298 | 0.76 | MAPT (0.37) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL22622062 | 0.76 | TSHR (0.52) | MEN1KMT2AALDH1A1TSHRENPP3 | |
| SCHEMBL2085730 | 0.75 | KMT2A (0.44) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL3268723 | 0.75 | NPC1 (0.56) | NPC1RAB9AMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 964 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118986933-A | Nanometer preparation for delivering medicine on demand aiming at inherent barrier of pancreatic cancer, and preparation method and application thereof | 复旦大学 | 2024-11-22 | — | — | CN | claimed |
| CN-117358321-B | Chromatography medium and preparation method thereof | 赛普(杭州)过滤科技有限公司 | 2024-03-19 | — | — | CN | claimed |
| CN-117358321-A | Chromatography medium and preparation method thereof | 赛普(杭州)过滤科技有限公司 | 2024-01-09 | — | — | CN | claimed |
| CN-116899633-B | Hydrophilic anion exchange chromatography medium and preparation method and application thereof | 赛普(杭州)过滤科技有限公司 | 2023-12-19 | — | — | CN | claimed |
| CN-116899633-A | Hydrophilic anion exchange chromatography medium and preparation method and application thereof | 赛普(杭州)过滤科技有限公司 | 2023-10-20 | — | — | CN | claimed |
| CN-112979881-B | Macromolecules, compositions and methods for enhancing anticancer drug uptake | 南开大学 | 2023-06-27 | — | — | CN | claimed |
| WO-2021121068-A1 | MACROMOLECULE FOR PROMOTING INTAKE OF ANTICANCER DRUG, AND COMPOSITION CONTAINING SAME AND USE THEREOF IN PREPARATION OF ANTICANCER DRUG | 南开大学 | 2021-06-24 | — | — | WO | claimed |
| CN-112979881-A | Macromolecule and composition for promoting anticancer drug intake and application thereof in preparing anticancer drugs | 南开大学 | 2021-06-18 | — | — | CN | claimed |
| EP-2542889-B1 | LIGAND GUANIDINYL FUNCTIONALIZED POLYMERS | 3M INNOVATIVE PROPERTIES CO (US) | 2015-03-25 | — | — | EP | claimed |
| US-8853276-B2 | Guanidine derivatives in cinnamic series | PRODUITS CHIMIQUES AUXILIAIRES ET DE SYNTHESE (FR) | 2014-10-07 | — | — | US | claimed |
| WO-2000002877-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | claimed |
| US-5928916-A | Ionic attachment of biomolecules with a guanidino moiety to medical device surfaces | MEDTRONIC, INC. (US) | 1999-07-27 | — | — | US | claimed |
| US-5925552-A | Method for attachment of biomolecules to medical devices surfaces | MEDTRONIC, INC. (US) | 1999-07-20 | — | — | US | claimed |
| EP-0546548-B1 | Guanidinyl alkyl-1,1-bis phosphonic acid derivatives, process for their preparation and their use | HOECHST AG (DE) | 1997-05-02 | — | — | EP | claimed |
| EP-0743573-A2 | Method for obtaining image contrast migration imaging members | XEROX CORPORATION (US) | 1996-11-20 | — | — | EP | claimed |
| EP-0743574-A2 | Migration imaging members | XEROX CORPORATION (US) | 1996-11-20 | — | — | EP | claimed |
| US-5563014-A | SOFTENABLE LAYER CONTAINIG PHOTOSENSITIVE MARKING MATERIAL; TRANSPARENTIZING AGENT | XEROX CORPORATION (US) | 1996-10-08 | — | — | US | claimed |
| US-5514505-A | SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE | XEROX CORPORATION (US) | 1996-05-07 | — | — | US | claimed |
| EP-0228034-B1 | ARGININE AND AGMATINE DERIVATIVES FOR TREATING PROTOZOAL INFECTIONS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-03 | — | — | EP | claimed |
| EP-0071919-A2 | Spiro(benzofuran-2(3H),4'(2'H)-isoquinoline)s, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-02-16 | — | — | EP | claimed |