Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRC | Q99895 | 4/20 | 0.87 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | ALPL | P05186 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CDH1 | P12830 | 1/20 | 0.54 |
| ▸ | APC | P25054 | 1/20 | 0.54 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.54 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KMO | O15229 | 2/20 | 0.53 |
| ▸ | PTGES | O14684 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10917470 | 0.93 | CTRC (1.00) | CTRCCA12ALPLKDM4EMEN1 | |
| SCHEMBL10917538 | 0.92 | CTRC (0.74) | CTRCCA12ALPLKDM4EMEN1 | |
| SCHEMBL30468141 | 0.92 | CTRC (0.74) | CTRCCA12ALPLKDM4EMEN1 | |
| SCHEMBL10919146 | 0.92 | CTRC (0.74) | CTRCCA12ALPLKDM4EMEN1 | |
| SCHEMBL10916870 | 0.90 | CTRC (0.72) | CTRCCA12ALPLKDM4EMEN1 | |
| SCHEMBL10916858 | 0.90 | CTRC (0.72) | CTRCCA12ALPLKDM4EMEN1 | |
| SCHEMBL10922370 | 0.90 | CTRC (0.77) | CTRCCA12ALPLKDM4EMEN1 | |
| SCHEMBL23698038 | 0.88 | CTRC (0.69) | CTRCCA12ALPLKDM4EMEN1 | |
| SCHEMBL10916714 | 0.87 | CTRC (0.78) | CTRCCA12ALPLKDM4EMEN1 | |
| SCHEMBL10917775 | 0.87 | CTRC (0.68) | CTRCCA12ALPLKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064385-B1 | 2,6-DIARYL-PYRIDINECARBOXYLIC ACIDS AND THEIR THERAPEUTIC UTILITY | THE UPJOHN COMPANY (US) | 1986-04-02 | — | — | EP | claimed |
| US-4377586-A | Diuretic 2,6-diaryl-4-pyridine carboxylic acids | THE UPJOHN COMPANY (US) | 1983-03-22 | — | — | US | claimed |
| EP-0064385-A1 | 2,6-Diaryl-pyridinecarboxylic acids and their therapeutic utility | THE UPJOHN COMPANY (US) | 1982-11-10 | — | — | EP | claimed |
| US-6979741-B2 | Acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2005-12-27 | — | — | US | disclosed |
| EP-1478437-B1 | ACC INHIBITORS | PFIZER PROD INC (US) | 2005-08-31 | — | — | EP | disclosed |
| EP-1478437-A1 | ACC INHIBITORS | Pfizer Products Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| US-20030187254-A1 | Acetyl-CoA carboxylase inhibitors | PFIZER INC. | 2003-10-02 | — | — | US | disclosed |
| WO-2003072197-A1 | ACC INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-09-04 | — | — | WO | disclosed |
| EP-0064385-B1 | 2,6-DIARYL-PYRIDINECARBOXYLIC ACIDS AND THEIR THERAPEUTIC UTILITY | THE UPJOHN COMPANY (US) | 1986-04-02 | — | — | EP | disclosed |
| US-4474791-A | Diuretic 2,6-diaryl-4-pyridine carboxylic acids | THE UPJOHN COMPANY (US) | 1984-10-02 | — | — | US | disclosed |
| US-4377586-A | Diuretic 2,6-diaryl-4-pyridine carboxylic acids | THE UPJOHN COMPANY (US) | 1983-03-22 | — | — | US | disclosed |
| EP-0064385-A1 | 2,6-Diaryl-pyridinecarboxylic acids and their therapeutic utility | THE UPJOHN COMPANY (US) | 1982-11-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187254-A1 | Acetyl-CoA carboxylase inhibitors | ACACA, ACACB, ACAT1 | CTRC 1337/4885CA12 3268/4885ALPL 1708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.