Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | COMT | P21964 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4825857 | 0.81 | ALDH1A1 (0.45) | SLC6A3ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL27978170 | 0.80 | MEN1 (0.52) | SLC6A3ALDH1A1OPRM1GAASMN1; SMN2 | |
| SCHEMBL20894092 | 0.78 | SMN1; SMN2 (0.69) | ALDH1A1GAAKLKB1SMN1; SMN2POLB | |
| SCHEMBL27658982 | 0.76 | PTGDR2 (0.45) | ALDH1A1GAAKLKB1SMN1; SMN2PTGDR2 | |
| SCHEMBL13801069 | 0.75 | ALDH1A1 (0.52) | ALDH1A1POLBPTGDR2MEN1KMT2A | |
| SCHEMBL4834573 | 0.75 | RAB9A (0.51) | ALDH1A1GAASMN1; SMN2POLBMAPT | |
| Hydrochloric Acid SCHEMBL27687372 | 0.75 | PTGDR2 (0.44) | ALDH1A1GAAKLKB1SMN1; SMN2PTGDR2 | |
| SCHEMBL4032013 | 0.75 | KLKB1 (0.56) | ALDH1A1GAAKLKB1SMN1; SMN2MAPT | |
| SCHEMBL14364229 | 0.75 | ALDH1A1 (0.46) | ALDH1A1GAASMN1; SMN2PTGDR2MAPT | |
| SCHEMBL427731 | 0.74 | SMN1; SMN2 (0.59) | ALDH1A1GAASMN1; SMN2MAPTCOMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365571-A1 | COMPOUNDS AND COMPOSITIONS AS Sppl2a INHIBITORS | NOVARTIS AG (CH) | 2023-11-16 | — | — | US | disclosed |
| US-20230365571-A1 | COMPOUNDS AND COMPOSITIONS AS Sppl2a INHIBITORS | NOVARTIS AG (CH) | 2023-11-16 | — | — | US | disclosed |
| EP-0804437-B1 | [a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USES THEREOF | MERCKLE GMBH (DE) | 2005-09-14 | — | — | EP | disclosed |
| US-5939415-A | A!-annellated pyrrole derivatives and their use in pharmacology | MERCKLE GMBH (DE) | 1999-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230365571-A1 | COMPOUNDS AND COMPOSITIONS AS Sppl2a INHIBITORS | SPPL2A, SPPL2B, BACE1 | SLC6A3 4077/4885ALDH1A1 3565/4885OPRM1 4719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.