Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GPR52 | Q9Y2T5 | 5/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20894092 | 0.88 | SMN1; SMN2 (0.69) | KLKB1ALDH1A1SMN1; SMN2MAPTGAA | |
| SCHEMBL27929449 | 0.85 | SCD (0.53) | KLKB1ALDH1A1SMN1; SMN2MAPTGAA | |
| SCHEMBL27727783 | 0.83 | CDC7 (0.47) | KLKB1ALDH1A1SMN1; SMN2MAPTGAA | |
| SCHEMBL4243016 | 0.83 | SMN1; SMN2 (0.76) | ALDH1A1SMN1; SMN2MAPTGAALMNA | |
| SCHEMBL4030637 | 0.79 | GPR52 (0.47) | KLKB1LMNACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL5034460 | 0.77 | KDM4E (0.69) | KLKB1ALDH1A1SMN1; SMN2MAPTGAA | |
| SCHEMBL14108821 | 0.75 | SMN1; SMN2 (0.56) | KLKB1ALDH1A1SMN1; SMN2MAPTGAA | |
| SCHEMBL6183830 | 0.75 | SLC6A3 (0.50) | KLKB1ALDH1A1SMN1; SMN2MAPTGAA | |
| SCHEMBL26011296 | 0.75 | LMNA (0.42) | ALDH1A1SMN1; SMN2MAPTGAALMNA | |
| SCHEMBL14109405 | 0.75 | SMN1; SMN2 (0.55) | KLKB1ALDH1A1SMN1; SMN2MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054408-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | Novartis Ag (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008127349-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | NOVARTIS AG (CH) | 2008-10-23 | — | — | WO | claimed |
| EP-2121671-A1 | 2-SUBSTITUTED 5-MEMBERED HETEROCYCLES AS SCD INHIBITORS | Novartis AG (CH) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008074835-A1 | 2-SUBSTITUTED 5-MEMBERED HETEROCYCLES AS SCD INHIBITORS | NOVARTIS AG (CH) | 2008-06-26 | — | — | WO | disclosed |