Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4A1 | P60842 | 1/20 | 0.58 |
| ▸ | DHODH | Q02127 | 9/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6181595 | 0.90 | ALDH1A1 (0.59) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| SCHEMBL116029 | 0.89 | DHODH (0.74) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| SCHEMBL30485644 | 0.84 | AURKA (0.58) | EIF4A1DHODHKDM4EPDE10ALMNA | |
| SCHEMBL22573242 | 0.84 | AURKA (0.58) | EIF4A1DHODHKDM4EPDE10ALMNA | |
| SCHEMBL6185429 | 0.84 | ALDH1A1 (0.70) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| SCHEMBL4251010 | 0.83 | DHODH (0.61) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| SCHEMBL29893763 | 0.82 | ESR1 (0.50) | EIF4A1DHODHKDM4EPDE10APOLB | |
| SCHEMBL23590326 | 0.82 | DHODH (0.67) | DHODHHIF1AHSD17B10TP53CYP1A2 | |
| SCHEMBL29617663 | 0.82 | DHODH (0.67) | DHODHHIF1AHSD17B10TP53CYP1A2 | |
| SCHEMBL23590028 | 0.81 | DHODH (0.62) | DHODHKDM4EHIF1AHSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6979741-B2 | Acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2005-12-27 | — | — | US | disclosed |
| EP-1478437-B1 | ACC INHIBITORS | PFIZER PROD INC (US) | 2005-08-31 | — | — | EP | disclosed |
| CN-1642599-A | ACC inhibitors | PFIZER PROD INC (US) | 2005-07-20 | — | — | CN | disclosed |
| EP-1478437-A1 | ACC INHIBITORS | Pfizer Products Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| US-20030187254-A1 | Acetyl-CoA carboxylase inhibitors | PFIZER INC. | 2003-10-02 | — | — | US | disclosed |
| WO-2003072197-A1 | ACC INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187254-A1 | Acetyl-CoA carboxylase inhibitors | ACACA, ACACB, ACAT1 | EIF4A1 2733/4885DHODH 783/4885KDM4E 2140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.