Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4345823 | 0.91 | CYP3A4 (0.42) | BCHEHPGDACHEKDM4EMAPK1 | |
| SCHEMBL4526534 | 0.80 | CYP3A4 (0.37) | BCHEHPGDACHEKDM4EMAPK1 | |
| SCHEMBL4354365 | 0.76 | BCHE (0.40) | BCHEHPGDACHEMAPK1TP53 | |
| SCHEMBL7288638 | 0.74 | PDPK1 (0.44) | KDM4EMAPK1TP53ALDH1A1MEN1 | |
| SCHEMBL9748612 | 0.74 | RAB9A (0.42) | KDM4EMAPTALDH1A1L3MBTL1NPC1 | |
| SCHEMBL4345682 | 0.73 | HPGD (0.40) | HPGDMAPK1MAPTALDH1A1MEN1 | |
| SCHEMBL11001713 | 0.72 | CYP3A4 (0.54) | HPGDKDM4EMAPTALDH1A1NPC1 | |
| SCHEMBL4347254 | 0.72 | CYP3A4 (0.54) | HPGDKDM4EMAPTALDH1A1NPC1 | |
| SCHEMBL10994406 | 0.71 | MYLK (0.43) | BCHEHPGDKDM4EALDH1A1NPC1 | |
| SCHEMBL4349307 | 0.71 | CYP3A4 (0.53) | BCHEHPGDACHEKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539723-A1 | NOVEL USE OF BENZOTHIAZOLE DERIVATIVES | AstraZeneca AB (SE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004016600-A1 | NOVEL USE OF BENZOTHIAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |