Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SORD | Q00796 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6183465 | 0.90 | PTPN11 (0.40) | PTPN11KDM4ESORDMAPTACHE | |
| SCHEMBL6183977 | 0.89 | SLC6A4 (0.42) | PTPN11SLC6A4SLC6A3KDM4EAKT1 | |
| SCHEMBL6183516 | 0.82 | KMT2A (0.45) | MAPTACHE | |
| SCHEMBL6186273 | 0.81 | KDM4E (0.48) | PTPN11SLC6A4KDM4EPOLBMAPT | |
| SCHEMBL5755134 | 0.78 | GFER (0.44) | AKT2GSK3BPTPN11SLC6A4SLC6A3 | |
| Trifluoroacetic Acid SCHEMBL4816285 | 0.73 | SMN1; SMN2 (0.39) | AKT2GSK3BKDM4EPOLBNPSR1 | |
| SCHEMBL6185472 | 0.72 | KDM4E (0.48) | SLC6A4KDM4EPOLBSORDMAPT | |
| SCHEMBL6183506 | 0.69 | KDM4E (0.47) | SLC6A4SLC6A3KDM4ESLC6A2MAPT | |
| Trifluoroacetic Acid SCHEMBL27607925 | 0.68 | SLC6A7 (0.38) | PTPN11KDM4EHTR1A | |
| SCHEMBL4806920 | 0.67 | MEN1 (0.46) | PTPN11SLC6A4SLC6A3KDM4EHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513835-A1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003104225-A1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2003-12-18 | — | — | WO | disclosed |