Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 10/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | DRD5 | P21918 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185942 | 0.96 | ABCB1 (0.60) | ABCB1DRD2DRD1DRD5DRD3 | |
| SCHEMBL6185349 | 0.92 | ABCB1 (0.53) | ABCB1DRD2DRD1DRD5DRD3 | |
| SCHEMBL6182349 | 0.87 | ABCB1 (0.58) | ABCB1DRD2DRD1DRD5DRD3 | |
| SCHEMBL6184672 | 0.87 | ABCB1 (0.53) | ABCB1DRD2DRD1DRD5DRD3 | |
| SCHEMBL6184251 | 0.86 | DRD1 (0.55) | ABCB1DRD1DRD5KCNH2 | |
| SCHEMBL6185944 | 0.85 | ABCB1 (0.51) | ABCB1DRD2DRD3KCNH2HTR1A | |
| SCHEMBL6187774 | 0.83 | ABCB1 (0.58) | ABCB1DRD2DRD3HTR1A | |
| SCHEMBL6182420 | 0.82 | ABCB1 (0.50) | ABCB1 | |
| SCHEMBL6185306 | 0.81 | HTR1A (0.48) | DRD2DRD3KCNH2HTR1A | |
| SCHEMBL6184263 | 0.78 | ABCB1 (0.51) | ABCB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275641-B1 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-01-12 | — | — | EP | disclosed |
| US-6541471-B1 | Useful as a TXA2 receptor antagonist and a 5-HT2 receptor antagonist | LES LABORATOIRES SERVIER (FR) | 2003-04-01 | — | — | US | disclosed |
| EP-1275641-A2 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |