Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325137 | 0.92 | CRBN (0.51) | ALDH1A1HSD17B10TSHRHTTHCRTR1 | |
| SCHEMBL13162369 | 0.85 | HPGD (0.59) | ALDH1A1CYP3A4CYP2C19HSD17B10CYP2D6 | |
| SCHEMBL14191187 | 0.82 | TSHR (0.75) | ALDH1A1CYP2C19HSD17B10USP2TSHR | |
| SCHEMBL5009820 | 0.79 | MAPT (0.62) | ALDH1A1CYP3A4CYP2C19CYP2D6CYP1A2 | |
| SCHEMBL14271965 | 0.79 | NAAA (0.68) | ALDH1A1HSD17B10USP2TSHRHTT | |
| SCHEMBL2577570 | 0.78 | L3MBTL1 (0.64) | ALDH1A1HSD17B10TSHRHTTHCRTR1 | |
| SCHEMBL3954494 | 0.78 | ALDH1A1 (0.56) | ALDH1A1CYP3A4CYP2C19HSD17B10CYP2D6 | |
| SCHEMBL7693312 | 0.78 | HDAC3 (0.56) | ALDH1A1HSD17B10HCRTR1KDM4EHPGD | |
| SCHEMBL13468193 | 0.76 | CHRM1 (0.55) | ALDH1A1HSD17B10USP2TSHRHTT | |
| SCHEMBL12818745 | 0.76 | TSHR (0.53) | ALDH1A1HSD17B10TSHRHTTHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1193257-B1 | Compounds for ceramide-mediated signal transduction | UNIV CALIFORNIA (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-0986561-B1 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | UNIV CALIFORNIA (US) | 2005-07-27 | — | — | EP | disclosed |
| US-6562819-B2 | Antiinflammatory agents; antiproliferative agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-05-13 | — | — | US | disclosed |
| US-20020165202-A1 | Compounds for inhibition of ceramide-mediated signal transduction | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-11-07 | — | — | US | disclosed |
| EP-1193257-A2 | Compounds for ceramide-mediated signal transduction | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-04-03 | — | — | EP | disclosed |
| US-6323201-B1 | ANTIINFLAMMATORY AGENTS, ANTIPROLIFERATION AGENTS AND ENZYME INHIBITORS OF PHOSPHODIESTERASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-11-27 | — | — | US | disclosed |
| EP-1091960-A1 | BIFUNCTIONAL ANTAGONISTS OF CYTOKINE-SENSITIVE PROTEIN KINASE ACTIVATION CASCADES AND METHODS FOR USE AS ANTI-INFLAMMATORY AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000000491-A1 | BIFUNCTIONAL ANTAGONISTS OF CYTOKINE-SENSITIVE PROTEIN KINASE ACTIVATION CASCADES AND METHODS FOR USE AS ANTI-INFLAMMATORY AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-01-06 | — | — | WO | disclosed |
| EP-0801568-A4 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | UNIV CALIFORNIA (US) | 1998-02-25 | — | — | EP | disclosed |
| EP-0801568-A1 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-10-22 | — | — | EP | disclosed |
| WO-1996020710-A1 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-07-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020165202-A1 | Compounds for inhibition of ceramide-mediated signal transduction | SMPD1, CERT1, SMPD3 | ALDH1A1 3282/4885NR1H4 1988/4885CYP3A4 4363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.