Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.52 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16689220 | 0.88 | LMNA (0.69) | LMNAL3MBTL1HRH3KEAP1NFE2L2 | |
| SCHEMBL23928219 | 0.83 | HRH3 (0.77) | HRH3KEAP1NFE2L2LTA4H | |
| SCHEMBL6183446 | 0.81 | HRH1 (0.51) | LMNAKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL30876469 | 0.81 | HRH3 (0.74) | HRH3KEAP1NFE2L2LTA4H | |
| SCHEMBL6185078 | 0.80 | PPARG (0.53) | LMNAL3MBTL1HRH3FFAR1LTA4H | |
| SCHEMBL8478544 | 0.78 | FFAR1 (0.71) | LMNAL3MBTL1FFAR1LTA4HPPARG | |
| SCHEMBL4842616 | 0.78 | FFAR1 (0.61) | LMNAL3MBTL1FFAR1FFAR4 | |
| SCHEMBL873847 | 0.77 | HRH3 (0.68) | LMNAL3MBTL1HRH3KEAP1NFE2L2 | |
| SCHEMBL6984230 | 0.77 | TBXA2R (0.60) | ALDH1A1 | |
| SCHEMBL6185574 | 0.76 | HRH1 (0.52) | LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275641-B1 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-01-12 | — | — | EP | disclosed |
| US-6541471-B1 | Useful as a TXA2 receptor antagonist and a 5-HT2 receptor antagonist | LES LABORATOIRES SERVIER (FR) | 2003-04-01 | — | — | US | disclosed |
| EP-1275641-A2 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |