Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD5 | P21918 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185574 | 0.94 | HRH1 (0.52) | HRH1KDM4ELMNA | |
| SCHEMBL6184510 | 0.94 | KDM4E (0.50) | HRH1KDM4E | |
| SCHEMBL6186059 | 0.89 | HRH1 (0.51) | HRH1DRD2DRD1DRD4DRD5 | |
| SCHEMBL6186189 | 0.83 | HRH1 (0.45) | HRH1DRD2DRD1DRD4DRD5 | |
| SCHEMBL6185595 | 0.81 | LMNA (0.56) | KDM4ELMNAALDH1A1 | |
| SCHEMBL6184672 | 0.80 | ABCB1 (0.53) | HRH1DRD2DRD1DRD4DRD5 | |
| SCHEMBL6186223 | 0.78 | TBXA2R (0.59) | — | |
| SCHEMBL6185286 | 0.78 | HRH1 (0.46) | HRH1KDM4E | |
| SCHEMBL11244476 | 0.78 | DRD2 (0.74) | HRH1DRD2DRD1DRD4DRD5 | |
| SCHEMBL6184251 | 0.77 | DRD1 (0.55) | HRH1DRD1DRD4DRD5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275641-B1 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-01-12 | — | — | EP | disclosed |
| US-6541471-B1 | Useful as a TXA2 receptor antagonist and a 5-HT2 receptor antagonist | LES LABORATOIRES SERVIER (FR) | 2003-04-01 | — | — | US | disclosed |
| EP-1275641-A2 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |