Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.48 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | ERN1 | O75460 | 2/20 | 0.43 |
| ▸ | JUN | P05412 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185924 | 1.00 | TRPA1 (0.53) | TRPA1ABL1ABCB1BCRTRIM24 | |
| SCHEMBL6187254 | 0.88 | TRPA1 (0.62) | TRPA1ABL1ABCB1BCRTRIM24 | |
| SCHEMBL6187259 | 0.88 | TRPA1 (0.62) | TRPA1ABL1ABCB1BCRTRIM24 | |
| SCHEMBL6184228 | 0.83 | NFKB1 (0.63) | TRPA1ABL1ABCB1BCRAR | |
| SCHEMBL6184219 | 0.83 | NFKB1 (0.63) | TRPA1ABL1ABCB1BCRAR | |
| SCHEMBL6184225 | 0.83 | NFKB1 (0.63) | TRPA1ABL1ABCB1BCRAR | |
| SCHEMBL6487475 | 0.79 | ALDH1A1 (0.55) | TRPA1NFE2L2APPALDH1A1LMNA | |
| SCHEMBL6487479 | 0.79 | ALDH1A1 (0.55) | TRPA1NFE2L2APPALDH1A1LMNA | |
| SCHEMBL3706037 | 0.73 | TRPA1 (0.67) | TRPA1ABL1ABCB1BCRNFKB1 | |
| SCHEMBL3706042 | 0.73 | TRPA1 (0.67) | TRPA1ABL1ABCB1BCRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275641-B1 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-01-12 | — | — | EP | disclosed |
| US-6541471-B1 | Useful as a TXA2 receptor antagonist and a 5-HT2 receptor antagonist | LES LABORATOIRES SERVIER (FR) | 2003-04-01 | — | — | US | disclosed |
| EP-1275641-A2 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |