Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.76 |
| ▸ | ALPI | P09923 | 1/20 | 0.76 |
| ▸ | NPC1 | O15118 | 5/20 | 0.72 |
| ▸ | RAB9A | P51151 | 5/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.62 |
| ▸ | CDK2 | P24941 | 1/20 | 0.62 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | AHR | P35869 | 1/20 | 0.59 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.53 |
| ▸ | SMO | Q99835 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4264906 | 0.85 | ALPL (0.78) | ALPLALPINPC1RAB9AMAPT | |
| SCHEMBL6564725 | 0.84 | RAB9A (1.00) | ALPLALPINPC1RAB9AMAPT | |
| SCHEMBL7130733 | 0.82 | RORC (0.62) | ALPLALPINPC1RAB9AMAPT | |
| SCHEMBL6566353 | 0.82 | NPC1 (1.00) | ALPLALPINPC1RAB9AMAPT | |
| SCHEMBL6562826 | 0.81 | NPC1 (1.00) | ALPLALPINPC1RAB9AMAPT | |
| SCHEMBL1663611 | 0.79 | NPC1 (0.89) | ALPLALPINPC1RAB9AMAPT | |
| SCHEMBL330223 | 0.77 | ALPL (0.65) | ALPLALPINPC1RAB9AMAPT | |
| SCHEMBL5786202 | 0.76 | SMO (0.49) | ALPLALPINPC1RAB9AMAPT | |
| SCHEMBL5867919 | 0.76 | CCNA2 (1.00) | CCNA2CDK2CCNA1 | |
| SCHEMBL18360452 | 0.76 | ALPL (0.54) | ALPLALPINPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788358-B1 | USE OF PYRAZOLE COMPOUNDS FOR THE TREATMENT OF GLOMERULONEPHRITIS, CANCER, ATHEROSCLEROSIS OR RESTENOSIS | MILLENNIUM PHARM INC (US) | 2004-03-31 | — | — | EP | disclosed |
| US-5916908-A | Pharmaceutical pyrazole compositions useful as inhibitors of protein kinases | COR THERAPEUTICS, INC. (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0788358-A2 | PHARMACEUTICAL PYRAZOLE COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | COR THERAPEUTICS, INC. (US) | 1997-08-13 | — | — | EP | disclosed |
| WO-1996014843-A2 | PHARMACEUTICAL PYRAZOLE COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | COR THERAPEUTICS, INC. (US) | 1996-05-23 | — | — | WO | disclosed |