Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | UNG | P13051 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6569493 | 0.84 | TP53 (0.41) | ACLYTRPM8MAPK1PPARAALDH1A1 | |
| SCHEMBL6187257 | 0.81 | SMN1; SMN2 (0.43) | TRIM24TRIM33BRD4DYRK1ADYRK2 | |
| SCHEMBL6264 | 0.80 | SMN1; SMN2 (0.43) | BRD4PPARAALDH1A1NPC1RAB9A | |
| SCHEMBL513853 | 0.77 | LMNA (0.54) | ACLYTRPM8PPARAALDH1A1NPC1 | |
| SCHEMBL8212790 | 0.77 | ACLY (0.53) | ACLYTRPM8MAPK1NPC1RAB9A | |
| SCHEMBL8205448 | 0.76 | XPO1 (0.48) | ACLYTRPM8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1823889 | 0.76 | TRPM8 (0.42) | ACLYTRPM8MAPK1PPARAALDH1A1 | |
| SCHEMBL926466 | 0.76 | LMNA (0.45) | ACLYTRPM8PPARAALDH1A1NPC1 | |
| SCHEMBL1092403 | 0.76 | AHR (0.45) | ACLYTRPM8PPARAALDH1A1NPC1 | |
| SCHEMBL1628780 | 0.76 | HSD17B2 (0.58) | ACLYTRPM8MAPK1PPARANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929553-B1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2005-03-16 | — | — | EP | disclosed |
| US-6251911-B1 | Pyrimidine derivatives and processes for the preparation thereof | NOVARTIS AG (CH) | 2001-06-26 | — | — | US | disclosed |
| EP-0929553-A1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998014450-A1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 1998-04-09 | — | — | WO | disclosed |
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |