Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 8/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4808560 | 0.89 | TDP1 (0.56) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL31758256 | 0.89 | TDP1 (0.61) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL30100913 | 0.88 | TDP1 (0.50) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL14682808 | 0.83 | TDP1 (0.48) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL31591658 | 0.83 | CTSK (0.50) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL14682815 | 0.83 | CTSK (0.50) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL14682796 | 0.82 | TDP1 (0.45) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL5024804 | 0.82 | MEN1 (0.55) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL23607315 | 0.82 | TDP1 (0.52) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL23607317 | 0.82 | TDP1 (0.52) | TDP1ATMNPSR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521742-A1 | DIPHENYLAZETIDINONE DERIVATIVES FOR TREATING DISORDERS OF THE LIPID METABOLISM | AstraZeneca AB (SE) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004005247-A1 | DIPHENYLAZETIDINONE DERIVATIVES FOR TREATING DISORDERS OF THE LIPID METABOLISM | ASTRAZENECA AB (SE) | 2004-01-15 | — | — | WO | disclosed |