Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 9/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14673894 | 0.91 | MEN1 (0.45) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL6186295 | 0.83 | TDP1 (0.51) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL31758256 | 0.82 | TDP1 (0.61) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL30100913 | 0.82 | TDP1 (0.50) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL26100893 | 0.80 | CAPN1 (0.46) | KMT2AMEN1ALDH1A1GAACTSS | |
| SCHEMBL26100889 | 0.80 | CAPN1 (0.46) | KMT2AMEN1ALDH1A1GAACTSS | |
| SCHEMBL18083185 | 0.80 | TDP1 (0.42) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL14682796 | 0.76 | TDP1 (0.45) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL14673895 | 0.76 | MEN1 (0.33) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL5024804 | 0.76 | MEN1 (0.55) | TDP1ATMNPSR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921571-B2 | Pyrrolysine analogs | THE OHIO STATE UNIVERSITY (US) | 2014-12-30 | — | — | US | disclosed |
| US-20130035478-A1 | PYRROLYSINE ANALOGS | THE OHIO STATE UNIVERSITY (US) | 2013-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035478-A1 | PYRROLYSINE ANALOGS | UROD, ALDH18A1, HMBS | TDP1 117/4885ATM 2830/4885NPSR1 730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.