Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.37 |
| ▸ | MMP2 | P08253 | 7/20 | 0.35 |
| ▸ | MMP9 | P14780 | 5/20 | 0.35 |
| ▸ | MMP8 | P22894 | 5/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.34 |
| ▸ | MMP12 | P39900 | 2/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | LIPC | P11150 | 1/20 | 0.33 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2869573 | 0.81 | PTGS2 (0.37) | LIPGMMP2MMP9MMP8ADAMTS5 | |
| SCHEMBL4838382 | 0.77 | KDM4E (0.47) | ADAMTS5ALDH1A1 | |
| SCHEMBL6190755 | 0.77 | SMN1; SMN2 (0.41) | MMP2MMP9MMP8ADAMTS5MMP12 | |
| SCHEMBL2872048 | 0.76 | KMT2A (0.42) | ALDH1A1 | |
| SCHEMBL2865158 | 0.74 | ADAMTS5 (0.41) | MMP2ADAMTS5MMP12ADAMTS4MMP3 | |
| SCHEMBL2872363 | 0.73 | MME (0.40) | MMP2MMP9MMP8 | |
| SCHEMBL12418505 | 0.72 | ALDH1A1 (0.50) | MMP2MMP9MMP8ALDH1A1 | |
| SCHEMBL12416711 | 0.72 | IL1RN (0.46) | MMP2MMP9MMP8ADAMTS5ALDH1A1 | |
| SCHEMBL2866828 | 0.72 | MAPT (0.46) | ALDH1A1 | |
| SCHEMBL2874365 | 0.72 | FFAR1 (0.40) | MMP2ADAMTS5MMP12ADAMTS4MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542977-A1 | 2,5-DIOXOIMIDAZOLIDIN-4-YL ACETAMIDES AND ANALOGUES AS INHIBITORS OF METALLOPROTEINASE MMP12. | AstraZeneca AB (SE) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004020415-A1 | 2,5-DIOXOIMIDAZOLIDIN-4-YL ACETAMIDES AND ANALOGUES AS INHIBITORS OF METALLOPROTEINASE MMP12. | ASTRAZENECA AB (SE) | 2004-03-11 | — | — | WO | disclosed |