Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206113 | 0.82 | ADAMTS5 (0.48) | ADAMTS5SMN1; SMN2PTGDR2FFAR1 | |
| SCHEMBL5205234 | 0.81 | TSHR (0.46) | SMN1; SMN2PTGDR2 | |
| SCHEMBL5205774 | 0.80 | ADAMTS5 (0.40) | ADAMTS5PTGDR2FFAR1 | |
| SCHEMBL5202388 | 0.80 | CNR1 (0.40) | HDAC1KDM4ECNR1 | |
| SCHEMBL5205241 | 0.80 | KDM4E (0.46) | KDM4ETAAR1SMN1; SMN2CNR1 | |
| SCHEMBL5208677 | 0.80 | NR3C1 (0.41) | HDAC1KDM4EHIF1ATAAR1SMN1; SMN2 | |
| SCHEMBL6177393 | 0.79 | ADAMTS5 (0.38) | HDAC1ADAMTS5PTGDR2 | |
| SCHEMBL6186419 | 0.79 | HDAC1 (0.43) | HDAC1KDM4EADAMTS5TAAR1CNR1 | |
| SCHEMBL5202191 | 0.78 | PPARG (0.42) | SMN1; SMN2PTGDR2FFAR1 | |
| SCHEMBL6177750 | 0.78 | ADAMTS5 (0.44) | ADAMTS5SMN1; SMN2PTGDR2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160887-B1 | Aromatic amine derivatives, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-09 | — | — | US | disclosed |
| EP-1123918-B1 | AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME | TAKEDA PHARMACEUTICAL (JP) | 2005-03-09 | — | — | EP | disclosed |
| EP-1123918-A1 | AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME | Takeda Chemical Industries, Ltd. (JP) | 2001-08-16 | — | — | EP | disclosed |