SCHEMBL6186477

SCHEMBL6186477

COc1ccc(S(=O)(=O)N2CCc3c(Br)cccc3C2)cc1N1CCN(C)CC1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 15/20 0.58
AKR1C3 P42330 2/20 0.54
CYP3A4 P08684 2/20 0.53
CYP2C19 P33261 2/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
USP2 O75604 1/20 0.51
LMNA P02545 1/20 0.51
GLA P06280 1/20 0.51
TSHR P16473 1/20 0.51
MAPK1 P28482 1/20 0.51
HSD17B10 Q99714 1/20 0.51
DRD3 P35462 2/20 0.48
CYP1A2 P05177 1/20 0.48
HTR1A P08908 1/20 0.48
CYP2D6 P10635 1/20 0.48
DRD2 P14416 1/20 0.48
HTR1D P28221 1/20 0.48
HTR1B P28222 1/20 0.48
HTR2A P28223 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27408461 0.86 CYP3A4 (0.73) HTR6CYP3A4CYP2C19SMN1; SMN2NPSR1
SCHEMBL6186315 0.84 HTR6 (0.78) HTR6CYP3A4CYP2C19SMN1; SMN2NPSR1
SCHEMBL6189325 0.84 HTR6 (0.61) HTR6AKR1C3CYP3A4CYP2C19SMN1; SMN2
Hydrochloric Acid SCHEMBL6187759 0.83 HTR6 (0.77) HTR6CYP3A4CYP2C19SMN1; SMN2NPSR1
Hydrochloric Acid SCHEMBL6186116 0.83 HTR6 (0.60) HTR6AKR1C3CYP3A4CYP2C19SMN1; SMN2
SCHEMBL6189296 0.82 HTR6 (0.64) HTR6CYP3A4CYP2C19SMN1; SMN2NPSR1
SCHEMBL6186320 0.82 HTR6 (0.82) HTR6AKR1C3CYP3A4CYP2C19SMN1; SMN2
SCHEMBL6186158 0.82 PKM (0.65) HTR6AKR1C3CYP3A4CYP2C19SMN1; SMN2
SCHEMBL6185622 0.82 HTR6 (0.59) HTR6CYP3A4CYP2C19SMN1; SMN2NPSR1
Hydrochloric Acid SCHEMBL6188988 0.82 HTR6 (0.63) HTR6CYP3A4CYP2C19SMN1; SMN2NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0994862-B1 SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION SMITHKLINE BEECHAM PLC (GB) 2005-06-01 EP claimed
CN-1087294-C Novel compounds SMITHKLINE BEECHAM PLC (GB) 2002-07-10 CN claimed
EP-0994862-B1 SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION SMITHKLINE BEECHAM PLC (GB) 2005-06-01 EP disclosed
CN-1087294-C Novel compounds SMITHKLINE BEECHAM PLC (GB) 2002-07-10 CN disclosed
US-6316450-B1 PIPERAZINE COMPOUNDS FOR TREATING DEPRESSION AND ANXIETY SMITHKLINE BEECHAM P.L.C. (GB) 2001-11-13 US disclosed
EP-0994862-A2 SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION SMITHKLINE BEECHAM PLC (GB) 2000-04-26 EP disclosed
WO-1999002502-A2 SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION SMITHKLINE BEECHAM PLC (GB) 1999-01-21 WO disclosed