SCHEMBL6186665

SCHEMBL6186665

Nc1cc(Cl)c([N+](=O)[O-])c(Cl)c1Br

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.48
TSHR P16473 2/20 0.48
MAPT P10636 4/20 0.46
LMNA P02545 2/20 0.46
NPC1 O15118 1/20 0.46
TP53 P04637 1/20 0.46
HPGD P15428 1/20 0.46
XBP1 P17861 1/20 0.46
HTT P42858 1/20 0.46
RAB9A P51151 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
TLR9 Q9NR96 1/20 0.46
CYP3A4 P08684 3/20 0.43
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
GRIN2D O15399 2/20 0.36
GRIN3B O60391 2/20 0.36
GRIN1 Q05586 2/20 0.36
GRIN2A Q12879 2/20 0.36
GRIN2B Q13224 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8873092 0.81 TSHR (0.53) ALDH1A1TSHRMAPTLMNANPC1
SCHEMBL7209293 0.76 GPR35 (0.48) ALDH1A1TSHRMAPTLMNAHPGD
SCHEMBL7471462 0.76 ALDH1A1 (0.50) ALDH1A1TSHRMAPTLMNANPC1
SCHEMBL5042912 0.75 TSHR (0.73) ALDH1A1TSHRMAPTLMNANPC1
SCHEMBL8874607 0.75 TSHR (0.59) ALDH1A1TSHRMAPTLMNANPC1
SCHEMBL1625816 0.75 TSHR (0.72) ALDH1A1TSHRMAPTLMNANPC1
SCHEMBL23000411 0.72 TSHR (0.50) ALDH1A1TSHRHPGDCYP3A4GRIN2D
SCHEMBL31330060 0.72 ALDH1A1 (0.42) ALDH1A1TSHRMAPTLMNANPC1
SCHEMBL11225269 0.71 ALDH1A1 (0.67) ALDH1A1TSHRMAPTLMNANPC1
SCHEMBL5921857 0.71 TSHR (0.74) ALDH1A1TSHRMAPTLMNANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0994862-B1 SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION SMITHKLINE BEECHAM PLC (GB) 2005-06-01 EP disclosed
CN-1087294-C Novel compounds SMITHKLINE BEECHAM PLC (GB) 2002-07-10 CN disclosed
US-6316450-B1 PIPERAZINE COMPOUNDS FOR TREATING DEPRESSION AND ANXIETY SMITHKLINE BEECHAM P.L.C. (GB) 2001-11-13 US disclosed
CN-1261883-A Novel compounds SMITHKLINE BEECHAM PLC (GB) 2000-08-02 CN disclosed
EP-0994862-A2 SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION SMITHKLINE BEECHAM PLC (GB) 2000-04-26 EP disclosed
WO-1999002502-A2 SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION SMITHKLINE BEECHAM PLC (GB) 1999-01-21 WO disclosed