Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12415749 | 0.90 | TSHR (0.53) | TSHRALDH1A1TDP1MAPTMEN1 | |
| SCHEMBL9387590 | 0.89 | TSHR (0.59) | TSHRALDH1A1TDP1MAPTMEN1 | |
| SCHEMBL30807893 | 0.89 | TDP1 (0.62) | TSHRALDH1A1TDP1MAPTMEN1 | |
| SCHEMBL2189138 | 0.88 | TSHR (0.54) | TSHRALDH1A1TDP1MAPTMEN1 | |
| SCHEMBL6297719 | 0.85 | TDP1 (0.58) | TSHRALDH1A1TDP1MAPTMEN1 | |
| SCHEMBL15157099 | 0.83 | TSHR (0.53) | TSHRALDH1A1TDP1MAPTMEN1 | |
| SCHEMBL6222813 | 0.82 | TSHR (0.55) | TSHRALDH1A1TDP1MAPTCYP3A4 | |
| SCHEMBL10385267 | 0.82 | TSHR (0.51) | TSHRALDH1A1TDP1MAPTMEN1 | |
| SCHEMBL9913609 | 0.82 | TSHR (0.51) | TSHRALDH1A1TDP1MAPTMEN1 | |
| SCHEMBL10360037 | 0.82 | TSHR (0.51) | TSHRALDH1A1TDP1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 203 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738679-B2 | Methods of synthesizing substituted purine compounds | Epizyme, Inc. (US) | 2017-08-22 | — | — | US | claimed |
| US-20160024134-A1 | METHODS OF SYNTHESIZING SUBSTITUTED PURINE COMPOUNDS | Epizyme, Inc. | 2016-01-28 | — | — | US | claimed |
| EP-2968387-A2 | METHODS OF SYNTHESIZING SUBSTITUTED PURINE COMPOUNDS | Epizyme, Inc. (US) | 2016-01-20 | — | — | EP | claimed |
| WO-2014152566-A2 | METHODS OF SYNTHESIZING SUBSTITUTED PURINE COMPOUNDS | Epizyme, Inc. (US) | 2014-09-25 | — | — | WO | claimed |
| US-8569356-B2 | Cyclin dependent kinase inhibitors | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-10-29 | — | — | US | claimed |
| US-20250282736-A1 | SMALL MOLECULE MODULATORS OF HUMAN PREGNANE X RECEPTOR | ST JUDE CHILDRENS RES HOSPITAL (US) | 2025-09-11 | — | — | US | disclosed |
| US-12043634-B2 | Metal complexes, methods of making the same, and uses thereof | THE UNIVERSITY OF MANITOBA (CA) | 2024-07-23 | — | — | US | disclosed |
| WO-2023205344-A1 | SMALL MOLECULE MODULATORS OF HUMAN PREGNANE X RECEPTOR | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2023-10-26 | — | — | WO | disclosed |
| US-20230287033-A1 | METHODS OF SYNTHESIZING SUBSTITUTED PURINE COMPOUNDS | Epizyme, Inc. | 2023-09-14 | — | — | US | disclosed |
| US-20230287033-A1 | METHODS OF SYNTHESIZING SUBSTITUTED PURINE COMPOUNDS | Epizyme, Inc. | 2023-09-14 | — | — | US | disclosed |
| US-11753433-B2 | Methods of synthesizing substituted purine compounds | Epizyme, Inc. (US) | 2023-09-12 | — | — | US | disclosed |
| US-11753433-B2 | Methods of synthesizing substituted purine compounds | Epizyme, Inc. (US) | 2023-09-12 | — | — | US | disclosed |
| EP-0039367-A4 | UV-ABSORBING COMPOUNDS AND PHOTOGRAPHIC ELEMENTS CONTAINING THEM. | MINNESOTA MINING & MFG (US) | 1982-07-12 | — | — | EP | disclosed |
| US-4323633-A | BUTYLATED 2-HYDROXYPHENYL BENZOTRIAZOLE | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1982-04-06 | — | — | US | disclosed |
| EP-0039367-A1 | UV-ABSORBING COMPOUNDS AND PHOTOGRAPHIC ELEMENTS CONTAINING THEM | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1981-11-11 | — | — | EP | disclosed |
| WO-1981001473-A1 | UV-ABSORBING COMPOUNDS AND PHOTOGRAPHIC ELEMENTS CONTAINING THEM | MINNESOTA MINING & MFG (US) | 1981-05-28 | — | — | WO | disclosed |
| US-4074046-A | REACTING NITROGENEOUS COMPOUND WITH CARBON MONOXIDE | AMERICAN CYANAMID COMPANY (US) | 1978-02-14 | — | — | US | disclosed |
| US-4009994-A | Process and product of optical brightening with quaternized benzofuranyl-benzimidazoles | CIBA-GEIGY CORPORATION (US) | 1977-03-01 | — | — | US | disclosed |
| US-3998804-A | PROCESS FOR COUPLING OF WATER-INSOLUBLE 2,4-DISUBSTITUTED PHENOLS WITH DIAZOTIZED O-NITROANILINES | CIBA-GEIGY CORPORATION (US) | 1976-12-21 | — | — | US | disclosed |
| US-3940417-A | Quaternised benzofuranyl-benzimidazoles | CIBA-GEIGY CORPORATION (US) | 1976-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12043634-B2 | Metal complexes, methods of making the same, and uses thereof | SOD1, CA2, SLC6A6 | TSHR 4578/4885ALDH1A1 1422/4885TDP1 1300/4885 |
| US-20160024134-A1 | METHODS OF SYNTHESIZING SUBSTITUTED PURINE COMPOUNDS | DOT1L, MECP2, TDP1 | TSHR 3824/4885ALDH1A1 652/4885TDP1 3/4885 |
| US-11753433-B2 | Methods of synthesizing substituted purine compounds | DOT1L, MECP2, TDP1 | TSHR 3824/4885ALDH1A1 652/4885TDP1 3/4885 |
| US-20250282736-A1 | SMALL MOLECULE MODULATORS OF HUMAN PREGNANE X RECEPTOR | NR1H4, NR1I2, NR1I3 | TSHR 437/4885ALDH1A1 3469/4885TDP1 3646/4885 |
| US-20230287033-A1 | METHODS OF SYNTHESIZING SUBSTITUTED PURINE COMPOUNDS | DOT1L, MECP2, TDP1 | TSHR 3824/4885ALDH1A1 652/4885TDP1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.