Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.51 |
| ▸ | WNT3A | P56704 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5934197 | 0.88 | ALDH1A1 (0.74) | LMNAALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL5934542 | 0.87 | MAPT (0.61) | LMNAALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL5934501 | 0.85 | MAPT (0.68) | LMNAMAPTTP53SMN1; SMN2MCHR1 | |
| SCHEMBL5934251 | 0.85 | RAB9A (0.55) | LMNAALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL30277601 | 0.83 | ALDH1A1 (0.74) | LMNAALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL5934266 | 0.82 | MAPT (0.62) | LMNAALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL5934510 | 0.82 | MAPT (0.64) | LMNAALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL5934079 | 0.82 | P4HTM (0.50) | LMNAALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL5934586 | 0.82 | ALDH1A1 (0.61) | LMNAALDH1A1MAPTTP53RAB9A | |
| SCHEMBL5934632 | 0.81 | TP53 (0.55) | ALDH1A1MAPTTP53SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575918-A2 | SUBSTITUTED BIARYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2005-09-21 | — | — | EP | claimed |
| WO-2004056774-A2 | SUBSTITUTED BIPHENYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2004-07-08 | — | — | WO | claimed |