Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | ATR | Q13535 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | WNT3A | P56704 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGDS | O60760 | 1/20 | 0.56 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5934542 | 0.87 | MAPT (0.61) | MAPTMCHR1TP53SMN1; SMN2DGAT1 | |
| SCHEMBL5934197 | 0.86 | ALDH1A1 (0.74) | MAPTMCHR1TP53SMN1; SMN2DGAT1 | |
| SCHEMBL5934510 | 0.86 | MAPT (0.64) | MAPTMCHR1TP53SMN1; SMN2DGAT1 | |
| SCHEMBL6186877 | 0.85 | LMNA (0.62) | MAPTMCHR1TP53SMN1; SMN2DGAT1 | |
| SCHEMBL5934277 | 0.85 | MAPT (0.63) | MAPTTP53SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL5934212 | 0.85 | MAPT (0.69) | MAPTTP53SMN1; SMN2DGAT1HDAC8 | |
| SCHEMBL5934793 | 0.85 | MAPT (0.63) | MAPTMCHR1TP53SMN1; SMN2DGAT1 | |
| SCHEMBL14082219 | 0.84 | MAPT (0.65) | MAPTTP53SMN1; SMN2DGAT1HDAC8 | |
| SCHEMBL5934266 | 0.84 | MAPT (0.62) | MAPTTP53SMN1; SMN2DGAT1HDAC8 | |
| SCHEMBL5934460 | 0.82 | MAPT (0.61) | MAPTTP53SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060100245-A1 | Substituted biphenyl-4-carboxylic acid arylamide analogues | NEUROGEN CORPORATION (US) | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100245-A1 | Substituted biphenyl-4-carboxylic acid arylamide analogues | HCAR2, AHR, HCAR3 | MAPT 3567/4885MCHR1 420/4885TP53 3452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.