Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | TP53 | P04637 | 6/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | THPO | P40225 | 3/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9850210 | 0.80 | CA12 (0.59) | CYP3A4KMT2ATP53CYP1A2CYP2C19 | |
| SCHEMBL3683320 | 0.78 | CYP3A4 (0.79) | CYP3A4KMT2ATP53CYP1A2CYP2C19 | |
| SCHEMBL26075093 | 0.78 | PKM (0.50) | KMT2ACA12CA9CA1CA2 | |
| SCHEMBL21569706 | 0.77 | L3MBTL1 (0.56) | CYP3A4KMT2ATP53CYP1A2CYP2C19 | |
| SCHEMBL7052844 | 0.77 | ATM (0.54) | KMT2ATSHRL3MBTL1ATMALDH1A1 | |
| SCHEMBL1081882 | 0.76 | POLB (0.40) | CYP3A4KMT2ATP53CYP1A2CYP2C19 | |
| SCHEMBL6565726 | 0.76 | CA12 (0.46) | CYP3A4KMT2ATP53CYP1A2CYP2C19 | |
| SCHEMBL31500481 | 0.76 | L3MBTL1 (0.51) | CYP3A4KMT2ATP53CYP1A2CYP2C19 | |
| SCHEMBL2371626 | 0.74 | ATM (0.50) | KMT2AMEN1TDP1L3MBTL1CA12 | |
| SCHEMBL13296442 | 0.74 | CYP3A4 (0.65) | CYP3A4KMT2ATP53CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521744-A1 | ARYLSULPHONAMIDE DERIVATIVES AND USE THEREOF AS B1 BRADYKININ RECEPTOR ANTAGONISTS | LABORATOIRES FOURNIER S.A. (FR) | 2005-04-13 | — | — | EP | disclosed |
| WO-2003106428-A1 | NOVEL ARYLSULPHONAMIDE DERIVATIVES AND USE THEREOF AS THERAPEUTIC AGENTS | LABORATOIRES FOURNIER SA (FR) | 2003-12-24 | — | — | WO | disclosed |