Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 10/20 | 0.49 |
| ▸ | LPAR5 | Q9H1C0 | 10/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.47 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3695128 | 0.89 | LPAR1 (0.46) | LPAR1LPAR5OPRM1OPRD1OPRK1 | |
| SCHEMBL3895438 | 0.87 | OPRM1 (0.64) | LPAR1LPAR5OPRM1OPRD1OPRK1 | |
| SCHEMBL3695195 | 0.79 | OPRM1 (0.76) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3691735 | 0.78 | OPRM1 (0.56) | LPAR1LPAR5OPRM1OPRD1OPRK1 | |
| SCHEMBL13285401 | 0.76 | OPRM1 (0.60) | LPAR1LPAR5OPRM1OPRD1OPRK1 | |
| SCHEMBL5739117 | 0.76 | LPAR1 (0.59) | LPAR1LPAR5 | |
| SCHEMBL6187615 | 0.76 | OPRM1 (0.54) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3690340 | 0.75 | OPRM1 (0.71) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3693707 | 0.75 | OPRM1 (0.71) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL14026038 | 0.74 | OPRM1 (0.60) | LPAR1LPAR5OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562595-A1 | DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004026305-A1 | DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONIST | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |