Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.57 |
| ▸ | ACE | P12821 | 4/20 | 0.57 |
| ▸ | CPA1 | P15085 | 2/20 | 0.57 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.57 |
| ▸ | CTSB | P07858 | 2/20 | 0.55 |
| ▸ | CTSS | P25774 | 2/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.51 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.51 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.51 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6268181 | 1.00 | MME (0.57) | MMEACECPA1ACE2CTSB | |
| SCHEMBL6190124 | 0.91 | HDAC1 (0.53) | MMEACECPA1ACE2CTSB | |
| SCHEMBL2185240 | 0.86 | ITGB3 (0.58) | MMEACECPA1ACE2CTSS | |
| SCHEMBL844471 | 0.86 | ITGB3 (0.58) | MMEACECPA1ACE2CTSS | |
| SCHEMBL7758997 | 0.86 | ITGB3 (0.58) | MMEACECPA1ACE2CTSS | |
| SCHEMBL6020166 | 0.86 | CTSS (0.76) | CTSBCTSSCTSLCTSK | |
| SCHEMBL3927408 | 0.86 | ACE (0.60) | MMEACECPA1ACE2ITGB3 | |
| SCHEMBL15201783 | 0.85 | MME (0.61) | MMEACECPA1ACE2ITGB3 | |
| SCHEMBL9936982 | 0.85 | MME (0.61) | MMEACECPA1ACE2ITGB3 | |
| SCHEMBL757454 | 0.84 | MME (0.62) | MMEACECPA1ACE2CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572669-A2 | 2,5-DIKETOPIPERAZINES FOR THE TREATMENT OF OBESITY | NOVO NORDISK A/S (DK) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004048345-A2 | 2,5-DIKETOPIPERAZINES FOR THE TREATMENT OF OBESITY | NOVO NORDISK A/S (DK) | 2004-06-10 | — | — | WO | disclosed |