Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | PGA5 | P0DJD9 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | CTSE | P14091 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | CCKAR | P32238 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6189972 | 0.88 | GAA (0.32) | GAAL3MBTL1PPARGKDM4EMAPT | |
| SCHEMBL6188226 | 0.84 | HTR2A (0.38) | GAAL3MBTL1HSD11B1PPARGMLNR | |
| SCHEMBL6186075 | 0.84 | MMP2 (0.33) | PPARGOPRD1KDM4EMAPTCYP3A4 | |
| SCHEMBL6189248 | 0.81 | CYP1A2 (0.34) | HSD11B1KDM4ECYP3A4HSD17B10LMNA | |
| SCHEMBL6189555 | 0.81 | CNR2 (0.36) | GAAL3MBTL1CYP3A4LMNAALDH1A1 | |
| SCHEMBL6191058 | 0.79 | KDM4A (0.34) | GAAL3MBTL1HSD11B1HTR2AOPRD1 | |
| SCHEMBL6187048 | 0.79 | GAA (0.36) | GAAL3MBTL1HSD11B1OPRD1 | |
| SCHEMBL6175679 | 0.78 | OPRD1 (0.48) | GAAL3MBTL1PPARGMLNRNR1I2 | |
| SCHEMBL6191220 | 0.77 | KDM4A (0.33) | GAAL3MBTL1HSD11B1HTR2AOPRD1 | |
| SCHEMBL6189357 | 0.77 | CNR2 (0.33) | KDM4ECYP3A4HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203770-B1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | UPJOHN CO (US) | 2005-03-09 | — | — | EP | claimed |
| EP-0668860-B1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | UPJOHN CO (US) | 2002-09-11 | — | — | EP | claimed |