Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.53 |
| ▸ | MC4R | P32245 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | CHKA | P35790 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14967181 | 0.87 | CYP2D6 (0.56) | HDAC6MCHR1HRH3KDM4EALDH1A1 | |
| SCHEMBL10396470 | 0.84 | CRHBP (0.58) | FAAHKDM4EALDH1A1 | |
| SCHEMBL27941363 | 0.84 | SIGMAR1 (0.49) | MCHR1FAAHHRH3LMNA | |
| SCHEMBL18374936 | 0.84 | HTT (0.54) | MCHR1HRH3LMNAALDH1A1 | |
| SCHEMBL374425 | 0.82 | KDM4E (0.50) | HDAC6MC4RFAAHLMNACHKA | |
| SCHEMBL17011749 | 0.82 | KMT2A (0.54) | FAAHKDM4EALDH1A1 | |
| SCHEMBL378576 | 0.81 | ALDH1A1 (0.55) | HDAC6MC4RHRH3LMNAACHE | |
| SCHEMBL21827026 | 0.80 | ALDH1A1 (0.50) | HDAC6MCHR1MC4RFAAHHRH3 | |
| SCHEMBL7404959 | 0.80 | SMN1; SMN2 (0.56) | HDAC6LMNAKDM4EALDH1A1 | |
| SCHEMBL16356429 | 0.80 | HDAC6 (0.69) | HDAC6MC4RHRH3LMNABTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1525200-A1 | 2-(3-AMINOARYL)AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITORS | AB Science (FR) | 2005-04-27 | — | — | EP | disclosed |
| WO-2004014903-A1 | 2-(3-AMINOARYL)AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITORS | AB SCIENCE (FR) | 2004-02-19 | — | — | WO | disclosed |