Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | STK17B | O94768 | 1/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ITK | Q08881 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185359 | 0.98 | MAOA (0.48) | MAOAMAOBNPSR1JAK2TYK2 | |
| SCHEMBL6185251 | 0.96 | HPGD (0.47) | MAOAMAOBNPSR1JAK2TYK2 | |
| SCHEMBL6185134 | 0.85 | MAOA (0.54) | MAOAMAOBNPSR1JAK2TYK2 | |
| SCHEMBL6186285 | 0.84 | MAOA (0.49) | MAOAMAOBNPSR1JAK2TYK2 | |
| SCHEMBL6189327 | 0.82 | HPGD (0.46) | MAOAMAOBNPSR1JAK2TYK2 | |
| SCHEMBL6187358 | 0.81 | F2R (0.51) | STK17BSTK17AALDH1A1KDM4EHPGD | |
| SCHEMBL6188627 | 0.80 | MAOB (0.47) | MAOAMAOBNPSR1JAK2TYK2 | |
| SCHEMBL6186848 | 0.79 | MAOB (0.49) | MAOAMAOBNPSR1JAK2TYK2 | |
| SCHEMBL6186086 | 0.78 | MAPT (0.39) | MAOAMAOBJAK2ALDH1A1SMN1; SMN2 | |
| SCHEMBL6187129 | 0.78 | GRM4 (0.51) | MAOAMAOBNPSR1STK17BSTK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554271-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035571-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2004-04-29 | — | — | WO | disclosed |