Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 4/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185251 | 0.80 | HPGD (0.47) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6187358 | 0.80 | F2R (0.51) | LMNAKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL6185359 | 0.78 | MAOA (0.48) | SMN1; SMN2MAOBMAOAKDM4EALDH1A1 | |
| SCHEMBL6188736 | 0.78 | MAOA (0.51) | SMN1; SMN2MAOBMAOAKDM4EALDH1A1 | |
| SCHEMBL6185706 | 0.76 | MAOB (0.42) | MAPTLMNATHRBSMN1; SMN2KMT2A | |
| SCHEMBL6187040 | 0.74 | NGFR (0.42) | MAPTLMNATHRBSMN1; SMN2KMT2A | |
| SCHEMBL6480667 | 0.71 | CHRNA7 (0.36) | MAPTLMNATHRBSMN1; SMN2KMT2A | |
| SCHEMBL6186247 | 0.70 | ALDH1A1 (0.67) | MAPTLMNAKMT2AMEN1HTT | |
| SCHEMBL6185825 | 0.67 | TYK2 (0.45) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6189327 | 0.66 | HPGD (0.46) | MAPTLMNASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554271-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035571-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2004-04-29 | — | — | WO | disclosed |