Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.34 |
| ▸ | DRD1 | P21728 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | PGA5 | P0DJD9 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CTSE | P14091 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6190123 | 0.91 | CYP2C9 (0.37) | OPRD1ADRA2AADRA2CDRD1ADRA1A | |
| SCHEMBL6175249 | 0.77 | MLNR (0.41) | SLC22A1OPRM1OPRD1ADRA2AADRA2C | |
| SCHEMBL6188998 | 0.76 | OPRD1 (0.34) | SLC22A1OPRM1OPRK1OPRD1SLC6A3 | |
| SCHEMBL7562120 | 0.76 | ALDH1A1 (0.31) | SLC22A1OPRM1OPRK1ALDH1A1HCAR3 | |
| SCHEMBL6188226 | 0.70 | HTR2A (0.38) | OPRD1ADRA2AADRA2CDRD1ADRA1A | |
| SCHEMBL6173540 | 0.68 | LDHA (0.40) | OPRM1OPRK1OPRD1ADRA2AADRA2C | |
| SCHEMBL25210900 | 0.68 | CYP17A1 (0.55) | SLC22A1OPRM1ADRA2AADRA2CDRD1 | |
| SCHEMBL27514771 | 0.68 | SLC22A1 (0.57) | SLC22A1OPRM1ADRA2AADRA2CDRD1 | |
| SCHEMBL6173274 | 0.67 | OPRD1 (0.39) | OPRM1OPRK1OPRD1ADRA2AADRA2C | |
| SCHEMBL6948749 | 0.64 | MLNR (0.49) | OPRD1ADRA2AADRA2CDRD1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203770-B1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | UPJOHN CO (US) | 2005-03-09 | — | — | EP | claimed |
| EP-0668860-B1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | UPJOHN CO (US) | 2002-09-11 | — | — | EP | claimed |