Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | IGFBP3 | P17936 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1650792 | 0.78 | ALDH1A1 (0.43) | ALDH1A1HPGDHSD17B10MAPK1CTNNB1 | |
| SCHEMBL9318696 | 0.77 | ALOX15 (0.58) | ALDH1A1HPGDALOX15HSD17B10SMN1; SMN2 | |
| SCHEMBL5553780 | 0.77 | MGAM (0.51) | ALDH1A1HPGDMAPK1CTNNB1SMN1; SMN2 | |
| Hydrogen Sulfide SCHEMBL28775857 | 0.75 | MGAM (0.50) | ALDH1A1HPGDMAPK1CTNNB1SMN1; SMN2 | |
| SCHEMBL6386860 | 0.75 | ALDH1A1 (0.56) | ALDH1A1HPGDALOX15HSD17B10MAPK1 | |
| SCHEMBL6386976 | 0.75 | ALOX15 (0.56) | ALDH1A1HPGDALOX15HSD17B10SMN1; SMN2 | |
| SCHEMBL6389963 | 0.75 | ALDH1A1 (0.47) | ALDH1A1MAPK1SMN1; SMN2TP53CYP1A2 | |
| SCHEMBL6386677 | 0.75 | ALOX15 (0.56) | ALDH1A1HPGDALOX15HSD17B10SMN1; SMN2 | |
| SCHEMBL6083926 | 0.73 | NPC1 (0.56) | ALDH1A1HPGDHSD17B10MAPK1SMN1; SMN2 | |
| SCHEMBL7255877 | 0.73 | NPC1 (0.56) | ALDH1A1HPGDHSD17B10MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1595871-A2 | Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases | NPS PHARMACEUTICALS, INC. (US) | 2005-11-16 | — | — | EP | disclosed |
| EP-1196397-B1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS AND THEIR USE FOR TREATING CENTRAL NERVOUS SYSTEM DISEASES | NPS PHARMA INC (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-1196397-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS AND THEIR USE FOR TREATING CENTRAL NERVOUS SYSTEM DISEASES | NPS PHARMACEUTICALS, INC. (US) | 2002-04-17 | — | — | EP | disclosed |
| WO-2000073283-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS AND THEIR USE FOR TREATING CENTRAL NERVOUS SYSTEM DISEASES | NPS PHARMACEUTICALS, INC. (US) | 2000-12-07 | — | — | WO | disclosed |